Select Help > Sample Data Library and open Design Experiment/Reactor Augment Data.jmp.
You want to maximize Percent Reacted. However, the column’s Response Limits column property in this sample data table is set to Minimize.
Change the Response Limits Column Property for the Percent Reacted Column
The Model script opens the Fit Model window with all main effects and two-factor interactions as effects.
Change the fitting personality from Standard Least Squares to Stepwise and then click Run.
In the Stepwise Regression Control panel, select P-value Threshold from the Stopping Rule menu and Mixed from the Direction menu. Enter 0.05 for the Prob to Enter and 0.1 for the Prob to Leave.
In the Current Estimates panel, select the Entered check boxes for all the main effect terms (Feed Rate - Concentration) and then click Go.
Completed Stepwise Model
Stepwise regression, beginning with the main effects and using a p-value based search, results in a model with 4 main effects and 3 interaction terms. The main effect Feed Rate was removed from the model while the Catalyst*Temperature, Stir Rate*Temperature, and Temperature*Concentration interactions were added to the model.
Click Make Model on the Stepwise control panel.
Click Run.
Prediction Model Analysis of Variance and Lack of Fit Tests
Click the Prediction Profiler red triangle and select Optimization and Desirability > Maximize Desirability.
Maximum Percent Reacted
The prediction profile plot in Maximum Percent Reacted shows that the maximum percent reaction occurs at high Catalyst, Stir Rate, and Temperature and low Concentration. At these extreme settings, the estimate of Percent Reacted is 98.38.

Help created on 9/19/2017