1.

You want to maximize Percent Reacted. However, the column’s Response Limits column property in this sample data table is set to Minimize.
2.

In the Columns panel of the data table, click the asterisk next to the Percent Reacted column name and select Response Limits, as shown on the left in Change the Response Limits Column Property for the Percent Reacted Column.

3.

In the Column Info dialog that appears, change the response limit to Maximize, as shown on the right in Change the Response Limits Column Property for the Percent Reacted Column.

4.

Click OK.

The Model script opens the Fit Model window with all main effects and twofactor interactions as effects.
6.

7.

In the Stepwise Regression Control panel, select Pvalue Threshold from the Stopping Rule menu and Mixed from the Direction menu. Enter 0.05 for the Prob to Enter and 0.1 for the Prob to Leave.

8.

In the Current Estimates panel, select the Entered check boxes for all the main effect terms (Feed Rate  Concentration) and then click Go.

Stepwise regression, beginning with the main effects and using a pvalue based search, results in a model with 4 main effects and 3 interaction terms. The main effect Feed Rate was removed from the model while the Catalyst*Temperature, Stir Rate*Temperature, and Temperature*Concentration interactions were added to the model.
9.

Click Make Model on the Stepwise control panel.

10.

Click Run.

The Actual by Predicted Plot indicates that the overall model is significant (P < 0.0001). Both the Actual by Predicted Plot and the Lack of Fit Test show no evidence of model misspecification. The Effect Summary report shows that Catalyst is the most significant effect. However, note that the three twofactor interactions are also significant.
11.

Click the Prediction Profiler red triangle and select Optimization and Desirability > Maximize Desirability.

The prediction profile plot in Maximum Percent Reacted shows that the maximum percent reaction occurs at high Catalyst, Stir Rate, and Temperature and low Concentration. At these extreme settings, the estimate of Percent Reacted is 98.38.