Suppose that you had chosen a traditional screening design instead of the definitive screening design in Definitive Screening Design. This example compares the two designs in terms of confounding.
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Select DOE > Classical > Screening Design.

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Select Load Factors From the red triangle next to Definitive Screening Design.

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Click Continue.

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Select Choose from a list of fractional factorial designs.

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Click Continue.

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Click Continue.

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Open the Display and Modify Design > Aliasing of Effects outline.

The Aliasing of Effects outline for the 16run fractional factorial design shows that every twofactor interaction is confounded with at least one other twofactor interaction. In this fractional factorial design, the Ethanol*Time interaction is confounded with Methanol*pH. To determine which interaction is active, you need to run additional trials. If the factors had been entered in a different order, the Ethanol*Time interaction might have been aliased with two other twofactor interactions.
In the section Definitive Screening Design, you constructed a 17run definitive screening design. The Color Map on Correlations for this DSD (Color Map on Correlations for Extraction Design) shows that no twofactor interactions are confounded with any other twofactor interactions. For the fractional factorial design, there are seven instances of confounded twofactor interactions. If you suspect that there are active twofactor effects, the DSD is the better choice.