AUC Calculation Method

Use this drop down widget to specify the method used to calculate the area under the curve (AUC).

Options include:

1.

Linear to regression start, then log-linear – area is estimated using observed concentrations before the regression start and log-concentrations from the start of regression onwards.

2.

Linear for the whole curve – area is estimated using the observed concentrations for the entire curve.

3.

Linear ascending, log-linear descending – area is estimated using a concentration when the previous concentration is less than or equal to the current concentration or the log concentration when the previous concentration is greater.

4.

Log-linear for the whole curve - area is estimated using the log-concentrations for the entire curve.