Output Overview Descriptions | Clinical Reports | Digit Preference

Digit Preference
This analysis assesses the use of terminal digits (either first or last in numerical findings) by study sites when reporting their clinical findings. It can be used to identify those sites that might exhibit biases in rounding issues or other problems with how they report data as compared with all other sites in the study.
Running Digit Preference for Nicardipine using default settings generates the report shown below.
The Report contains the following elements:
Digit Preference Volcano Plot : Each point represents the comparison of a site to all other sites. This comparison is used to determine whether there is a difference in distribution for the last digit for a findings test with numeric data available and is done for all sites across all tests in all findings domains.
The y -axis is the -log 10 ( Chi -Square Row Mean Score p-value ), which takes advantage of the ordinality of the final digit value, This test uses standardized midrank scores in case there are gaps due to certain digit values not present. Midranks are a way of scoring the columns when the distance between levels does not necessarily have a practical interpretation. Large numbers on the y -axis indicate statistically significant results.
The x -axis is the maximum percent difference across all digits between a site versus all sites.
Values far from 0 indicate important differences between a site and the reference distribution of all other sites. An FDR ( alpha =0.05) line is indicated by the dotted red line. Values above this line can be considered significant adjusting for multiple comparisons. This could identify rounding issues or other problems with how a site reports a particular test compared to other sites.
Test Results (Digit Preference) : One or more sections displaying distributions for subjects’ tests across study sites. There is a separate set of distributions for each Findings domain.
Drill Down Buttons
Drill down buttons provide you with an easy way to drill down into your data. The following drill down buttons are generated by this process:
Show Sites : Shows the rows of the data table for the selected points from the volcano plot . Use your mouse to select one or more sites of interest before clicking this button, as shown below:
Clicking opens the following table:
Digit Bar Charts : Clicking displays a bar chart , comparing the last digit distribution between selected sites versus all others, for the points selected in the table. This gives the user the ability to compare just how different each site is for a particular test. The underlying data table is available by going to Script > Data Table Window . The following chart shows the sites/tests selected above:
In this example, site 16 shows a marked preference for using reporting diastolic pressure with a terminal digit of “0”.
Click to generate a standardized pdf - or rtf -formatted report containing the plots and charts of selected sections.
Click the Options arrow to reopen the completed process dialog used to generate this output.