Bubble Plot of LB

The Bubble Plot of LB section contains the following elements:

•	One JMP bubble plot to display findings measurements across time. (See Bubble Plot for a general description of bubble plots.)

This plot is useful for viewing findings measurements and their trends across time through animation. Two findings measurements are selected by default to be shown on the X -axis and Y -axis. Default measurements plotted by domain are as follows:

Domain	Default measurement(s) plotted (if found in data)
laboratory measurements ( LB )	• LBTESTCD for the Bilirubin and Alanine Transaminase tests This view is helpful with visualization of subjects that might be experiencing liver injury.
vital signs ( VS )	• Diastolic and systolic blood pressure
electrocardiograms ( EG )	• Heart rate versus (corrected) QT interval
any other findings domain	• The first two tests in the data Alternatively, you can specify the two tests that are to show on the axes on the Display tab of the input dialog .

Each point or "bubble" represents the pair of findings measurements for a subject, colored by treatment arm or the selected treatment variable . Treatments are represented by the colors shown in the Treatment Legend . The animation can be started by clicking on the play ( ) button found with other Plot and Animation Controls at the bottom of the plot. When you click play , you start to see the bubbles move to show each subject's measurements for the findings plotted as study day (or week) progresses. Note that by default, the analysis linearly interpolates findings values for time points when a test was not measured. This is similar to viewing a timeline display and drawing a line between points of measurement. The Linearly interpolate values option is checked by default on the dialog so that bubble points do not appear and disappear in the visualization.

The Time Unit is shown in gray text in the white space of the plot. You can stop the display by clicking the pause ( ) button , or use the other Plot and Animation Controls to view the plot at a specific time point ( step backward ( ) button , step forward ( ) button , or Study Day of Specimen Collection slider), increase or decrease the speed of the animation ( Speed slider), or change the size of the bubbles ( Circle Size slider).

If you are analyzing laboratory measurements, the tests can be normalized by the ULN, LLN, or a Geometric method that references both ULN and LLN. Tests can also be transformed to log scaling. An Axis Legend on the right of the plot shows how gray reference lines or gray boxes of reference are drawn to highlight abnormal measurements.

Variable Roles are shown in boxes along the top of the bubble plot. These roles can be used to change the view to show alternate findings tests on the X and Y axes.

See the JMP Bubble Plot Platform for more information.

The bubble plot displayed on this tab is very useful to learn how your findings data behaves across the time of the trial. It is particularly informative at highlighting outliers in your data or measurements at an unusually high or low value for an unexpected length of time during the trial. This is especially useful with the laboratory measurements for evaluation of hepatotoxicity following Hy's Law. For electrocardiograms , it can highlight cardiotoxicity by showing extended QT intervals at given heart rate measurements. Subjects that show unusual temporal measurement in this plot can be easily profiled. Alternatively, the other available action button drill downs can be used to gather more information about your study.