Reports | AE Time to Event

AE Time to Event report screens all by performing log-rank and between treatment groups. The time to first occurrence of the adverse event is used as the response.
: If you run this analysis using data from a blinded study or from a study that has only one ARM, you generate a different set of output. See AE Time to Event (One ARM) for a detailed description
AE Time to Event report screens all adverse events by performing log-rank and Wilcoxon tests between treatment groups. The time to first occurrence of the adverse event is used as the response.
Running this report with the Nicardipine sample setting generates the tabbed Results shown below.
Presents summary figures for two popular statistical tests for Kaplan-Meier analyses: the Log-Rank and Wilcoxon .
The Volcano Plots section contains the following elements:
 • Two Volcano Plots .
The Y axis represents the -log 10 (raw p-value ) from either the Log-Rank test ( left ) or the Wilcoxon test ( right ). In most instances, these two tests coincide. To interpret this axis, consider the following.
1. a p -value of 1 equals 0 on the -log 10 scale,
2. a p -value of 0.1 equals 1 on the -log 10 scale,
3. a p -value of 0.01 equals 2 on the -log 10 scale,
4. a p -value of 0.001 equals 3 on the -log 10 scale,
5. a p -value of 0.0001 equals 4 on the -log 10 scale.
The X axis represents the maximum computed distance between the two curves, and color indicates which treatment was likely to have the event sooner. For example, Phlebitis occurs at approximately 0.27 on the X axis and is green . This means that at least one time point in the , the risk of having this particular event was 27% more likely for Nicardipine versus Placebo.
Events above the dotted red line are considered statistically significant after adjusting for multiple comparisons. Adjustment is applied using the linear step-up method of Benjamini and Hochberg (1995) to control the false discovery rate.