Reports | Findings Bubble Plot

Findings Bubble Plot
This report tracks a pair of findings measurements over time with an animated bubble plot . Values are linearly interpolated over time. You can select subjects of interest to display their time profiles.
For the LB domain, lab measurements are standardized by a reference midrange derived from the lower limit of normal (LLN) and upper limit of normal (ULN) to facilitate comparisons. The standardization centers the values at the midpoint between the LLN and the ULN and scales by (ULN - LLN)/2.
Note : JMP Clinical uses a special protocol for data including non-unique Findings test names. Refer to How does JMP Clinical handle non-unique Findings test names? for more information.
Report Results Description
Running Findings Bubble Plot with the Nicardipine sample setting and LB findings domain generates the tabbed Results shown below.
Note : For this example, an Ending Time Value of 14 was entered on the Display portion of the Options dialog because most measurements were taken only in the first two weeks of the study.
Bubble Plot of LB
Displays a JMP Bubble Plot of findings values for each subject in a study that can be animated to view findings measurements across the study days or weeks of a trial. Note that the name of the section is dependent on the current findings domain being analyzed. The section is named " Bubble Plot of XX " where XX is the domain specified on the dialog .
This section contains one JMP bubble plot to display findings measurements across time. (See Bubble Plot for a general description of bubble plots.)
This plot is useful for viewing findings measurements and their trends across time through animation. Two findings measurements are selected by default to be shown on the X axis and Y axis. Default measurements plotted by domain are as follows:
LBTESTCD for the Bilirubin and Alanine Transaminase tests
Each point or "bubble" represents the pair of findings measurements for a subject, colored by treatment arm or the selected treatment variable . Treatments are represented by the colors shown in the Treatment Legend . The animation can be started by clicking on the play ( ) button found with other Plot and Animation Controls at the bottom of the plot. When you click play , you start to see the bubbles move to show each subject's measurements for the findings plotted as study day (or week) progresses. Note that by default, the analysis linearly interpolates findings values for time points when a test was not measured. This is similar to viewing a time line display and drawing a line between points of measurement. The Linearly interpolate values option is checked by default on the dialog so that bubble points do not appear and disappear in the visualization.
The Time Unit is shown in gray text in the white space of the plot. You can stop the display by clicking the pause ( ) button , or use the other Plot and Animation Controls to view the plot at a specific time point ( step backward ( ) button , step forward ( ) button , or Study Day of Specimen Collection slider), increase or decrease the speed of the animation ( Speed slider), or change the size of the bubbles ( Circle Size slider).
If you are analyzing laboratory measurements, the tests can be normalized by the ULN, LLN, or a Geometric method that references both ULN and LLN. Tests can also be transformed to log scaling. An Axis Legend on the right of the plot shows how gray reference lines or gray boxes of reference are drawn to highlight abnormal measurements.
Variable Roles are shown in boxes along the top of the bubble plot. These roles can be used to change the view to show alternate findings tests on the X and Y axes.
See the JMP Bubble Plot Platform for more information.
The bubble plot displayed in this section is very useful to learn how your findings data behaves across the time of the trial. It is particularly informative at highlighting outliers in your data or measurements at an unusually high or low value for an unexpected length of time during the trial. This is especially useful with the laboratory measurements for evaluation of hepatotoxicity following Hy's Law. For electrocardiograms , it can highlight cardiotoxicity by showing extended QT intervals at given heart rate measurements. Subjects that show unusual temporal measurement in this plot can be easily profiled. Alternatively, the other available action button downs can be used to gather more information about your study.
Data Filter
This enables you to subset subjects based on demographic characteristics and other factors. Refer to Data Filter for more information.
Action Buttons
Action buttons, provide you with an easy way to drill down into your data. The following action buttons are generated by this report:
Profile Subjects : Select subjects and click to generate the patient profiles. See Profile Subjects for additional information.
Profile Subjects : Select subjects and click to open the ADSL (or DM if ADSL is unavailable) of selected subjects.
Cluster Subjects : Select subjects and click to cluster them using data from available covariates . See Cluster Subjects for additional information.
Demographic Counts : Select subjects and click to create a data set of USUBJID s, which subsets all subsequently run reports to those selected subjects. The currently available filter data set can be applied by selecting Apply Subject Filter in any report dialog .
Graph Time Trends : Select one or more points on the bubble plot and click the , as shown below, to drill down to a Trellis Plot for each subject selected.
Initially, the plots display the two Findings tests that were shown on the X axis and Y axis in the original bubble plot on the Y axis (in this case ( BILI and ALT levels), as shown below.
You can select more Findings tests to add to the Y axis by clicking in the Variables panel on the left side of the plot and dragging selected tests to the right of the Y axis of one of the subject plots. For example, you can select ALP and AST by clicking on ALP , then while holding Ctrl , also click AST and drag them both over until the light blue box appears as in the following figure:
Click to generate a standardized pdf - or rtf -formatted report containing the plots and charts of selected sections.
Click the Options arrow to reopen the completed report dialog used to generate this output.
Click the gray border to the left of the Options tab to open a dynamic report navigator that lists all of the reports in the review. Refer to Report Navigator for more information.
Report Options
Report Option Descriptions
Specific documentation for each of the options can be viewed by clicking on the following links:
General Options
Findings Domain to Analyze , Findings Domain Tests for Analysis
Treatment or Comparison Variable to Use , Treatment or Comparison Variable
Linearly interpolate values , Normalization of Lab Measurements , log Transformation of Lab Measurements
Subject Filter 1
Additional Filters
Additional Filter to Include Subjects 2 , Merge supplemental domain , Include the following findings records: , Additional Filter to Include Findings Tests , Select the population to include in the analysis , By Variables
x-Axis Findings Test Short Name Value , Y-Axis Findings Test Short Name Value , Set custom reference lines for bubble plot , Set reference line for x-Axis , Set reference line for y-Axis
Time Scale , Starting Time Value , Ending Time Value

Subject-specific filters must be created using the Create Subject Filter report prior to your analysis.

For more information about how to specify a filter using this option, see The SAS WHERE Expression .