Multiple Testing Method

This drop-down menu enables you to adjust your model for multiple hypothesis tests across all Means or LSMeans differences.

Note: If you do not specify Means or LSMeans differences, p-value adjustments are made across the Type 3 tests for all of the fixed effects and covariates.

The AdaptiveHolm, AdaptiveHochberg, Bonferroni, Holm, Hommel, Sidak, StepBon, and StepSid methods all control for the familywise error rate. The methods based on FDR all control for false discovery rate.

Multiple Testing Method

Definition

None

Select this option to enable the -log10(p-Value) Cutoff field. This selection enables you to specify a -log10(p-value) cutoff directly.

AdaptiveHolm

Requests adjusted p-values by using the Hochberg and Benjamini (1990)1 adaptive step-down Bonferroni method.

AdaptiveHochberg

Requests adjusted p-values by using the Hochberg and Benjamini (1990)1 adaptive step-up Bonferroni method.

Bonferroni

Specifies that the Bonferroni adjustments (number of tests p-value) be computed for each test.

Note: These adjustments can be extremely conservative and should be viewed with caution.

Hochberg

Assumes that p-values are independent and uniformly distributed under their respective null hypotheses, Hochberg (1988)2 demonstrates that Holm’s step-down adjustments control the familywise error rate even when calculated in step-up fashion. Since the adjusted p-values are uniformly smaller for Hochberg’s method than for Holm’s method, the Hochberg method is more powerful. However, this improved power comes at the cost of having to make the assumption of independence.

Hommel

Requests adjusted p-values by using the method of Hommel (1988)3.

Holm

See StepBon, below.

Sidak

Computes the Šidák adjustment for each test.

Note: These adjustments are slightly less conservative than the Bonferroni adjustments, but they still should be viewed with caution.

StepBon

Requests adjusted p-values by using the step-down Bonferroni method of Holm (1988).

StepSid

Requests adjusted p-values by using the Šidák method but in step-down fashion.

AdaptiveFDR

Requests adjusted p-values by using the Benjamini and Hochberg (2000)4 adaptive linear step-up method.

Dependent FDR

Requests adjusted p-values by using the method of Benjamini and Yekateuli (2001)5.

FDR

Requests adjusted p-values by using the linear step-up method of Benjamini and Hochberg (1995)6.
These p-values do not control the familywise error rate, but they do control the false discovery rate.

pFDR

Computes the "q-values" of Storey (2002) and Storey, Taylor, and Siegmund (2004). PROC MULTTEST treats these "q-values" as adjusted p-values.
The computations depend on estimating the number of true null hypotheses, and results are less conservative than FDR.

To Specify a Multiple Testing Method:

8 Make a selection using the drop-down menu.

Refer to p-Value Adjustments for more details about each of these methods.