Method to Use

Use this parameter to specify the method to use for combining study results.

To Specify the Method for Combining Studies:

Select This Method;	When you want to:
Inverse Variance - Fixed Ef fect Model	Calculates an average of the Effect Estimate or Direction Variable, weighted by the inverse variance, which is the inverse square of the Standard Error Variable. A z-score is calculated based on this new effect size and its standard error, and the two-sided p-value for it is reported along with heterogeneity statistics and, for selected SNPs, a forest plot.
Inverse Variance - Random Effect Model	Calculates an average of the Effect Estimate or Direction Variable, weighted by the inverse variance and an estimate of the between-study variance. A z-score is calculated based on this new effect size and its standard error, and the two-sided p-value for it is reported along with heterogeneity statistics and, for selected SNPs, a forest plot.
P-Values Weighted by Square Root of Sample Size	Use the p-Value Variable, convert it to a z-score with sign based on the sign of the Effect Estimate or Direction Variable, and weight it by the square root of the Sample Size Variable. The two-sided p-value for this z-score is reported.

Select the desired method by clicking within the appropriate radio button.