Processes | Genetics | p-Value Combination Method

p -Value Combination Method
This feature enables you to specify a method for combining p-values in each analysis group.
P -Value Combination Method 1
Takes the smallest p -value in the group and applies the Sidak correction to obtain the correct p -value
Replaces the p -value at the center of the sliding window with the p -value of the t-statistic .
Replaces the p -value at the center of the sliding window with the p -value computed using Simes’ method 2 .
Replaces the p -value at the center of the sliding window with the p -value computed using Zaykin’s method 3 .
The TPM is a variation of Fisher’s method that leads to a different alternative hypothesis . With the TPM, rejection of the null hypothesis implies that there is at least one false null hypothesis among those with p -values less than the specified tau value .
Note : This method is equivalent to Fisher’s method when tau =1.

1
Selected methods are not available in all processes.

2
Simes, R.J. (1986). An Improved Bonferroni Procedure for Multiple Tests of Significance. Biometrika 73: 751–754.

3
Zaykin, D.V., Zhivotovsky, L.A., Westfall, P.H., and Weir, B.S. (2002). Truncated Product Method for Combining p -Values. Genetic Epidemiology 22: 170–185.

To Specify a P -Value Combination Method:
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For Additional Information
For more information about these methods, see the Methods of Smoothing p -Values in the SAS/Genetics User's Guide.