Findings Bubble Plot

This process tracks a pair of findings measurements over time with an animated bubble plot . Values are linearly interpolated over time. You can select subjects of interest to display their time profiles.

For the LB domain, lab measurements are standardized by a reference midrange derived from the lower limit of normal (LLN) and upper limit of normal (ULN) to facilitate comparisons. The standardization centers the values at the midpoint between the LLN and the ULN and scales by (ULN - LLN)/2.

What do I need?

This process requires several demographic-, electrocardiogram -, laboratory-, and vital sign -related variables . These include:

•

USUBJID ,

•	a treatment variable ( the actual treatment received by each subject ( TRT01A )),

•	the planned treatment (intent-to-treat) for each subject ( TRT01P ), or the description of the planned treatment arm ( ARM ), and

•	variables for the EG ( EGTEST , EGTTESTCD , EGSTRESN , EGBLFL , and EGDTC ), LB ( LBTEST , LBTESTCD , LBSTRESN , LBBLFL , LBDTC , LBSTNRHI , and LBSTNRLO ), or VS ( VSTEST , VSTESTCD , VSSTRESN , VSBLFL , and VSDTC ) domains.

Variables can be taken either from the subject level analysis data set ( ADSL ) included in the Analysis Data Model ( ADaM ) folder or from the DM, EG, LB, and VS domains in SDTM .

Data from the Basic Data Structure (BDS) ADaM data sets can also be used for selected JMP Clinical Findings Reports. BDS variables are required and equated with SDTM variables, as follows: PARAMCD = xxTESTCD , AVAL = xxSTRESN , where xx indicates the specific two letter SDTM findings domain ( LB , EG , or VS ). In addition, when BDS is used, AVALC substitutes for xxSTRESC .

Refer to Localization-Specific Value Specification for more information about these data sets.

Output/Results

The output generated by this process is summarized by a tabbed report. Refer to the Findings Bubble Plot output documentation for detailed descriptions and guides to interpreting your results.