Parameters | Annotation Analysis | Enrichment Tests

Enrichment Tests
Select one or more methods for testing for enrichment. The method is applied separately for each significance variable that you specify.
The Fisher Exact test first creates 0-1 variables from the significance variables based on the Significance Variable Cutoff for Fisher Exact Tests specified below. (If you have already specified 0-1 variables, then any cutoff between 0 and 1 works.) It then constructs 2 x 2 tables for each category and uses the hypergeometric distribution to compute p-values . Refer to the documentation of PROC MULTTEST in SAS/STAT for details.
The Cochran-Armitage linear trend test is constructed for each variable by discretizing it into bins , alleviating the need for a single arbitrary significance cutoff. You can adjust the number of bins in the Number of Bins for Cochran-Armitage Tests specified below. Refer to the documentation of PROC MULTTEST in SAS/STAT for details.
The PAGE test works by constructing a two-sided z -score for each category as described in Kim and Volsky, BMC Bioinformatics. 2005; 6: 144. The z -score is computed as:
( Category Mean - Overall Mean )*sqrt( Frequency )/( Overall Std ).
To Specify Enrichment Tests:
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Highlight a single test, or hold down Ctrl while left-clicking on multiple tests, in the Enrichment Tests field.