Parameters | Expression Parameters | Apply weighting approach for trimmed mean

Apply weighting approach for trimmed mean
Check this box to apply a weighting approach when constructing the trimmed mean on the M component.
The weights are the inverse of the corresponding variance , assuming the counts of an individual sample are multinomially distributed.
Please refer to Robinson and Oshlack (2010; http://genomebiology.com/2010/11/3/R25 ) for more details.