Parameters | Genetics | Method to Use

Calculates an average of the Effect Estimate or Direction Variable, weighted by the inverse variance, which is the inverse square of the Standard Error Variable.A z-score is calculated based on this new effect size and its standard error, and the two-sided p-value for it is reported along with heterogeneity statistics and, for selected SNPs, a forest plot. Calculates an average of the Effect Estimate or Direction Variable, weighted by the inverse variance and an estimate of the between-study variance.A z-score is calculated based on this new effect size and its standard error, and the two-sided p-value for it is reported along with heterogeneity statistics and, for selected SNPs, a forest plot. Use the p-Value Variable, convert it to a z-score with sign based on the sign of the Effect Estimate or Direction Variable, and weight it by the square root of the Sample Size Variable.