Parameters | P-Value Operations | p-Value Combination Method

p-Value Combination MethodThis feature enables you to specify a method for combining p-values in each analysis group.

P-Value Combination Method

• Takes the smallest p-value in the category and applies the Sidak correction to obtain the adjusted p-value

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• The TPM is a variation of Fisher’s method that leads to a different alternative hypothesis. With the TPM, rejection of the null hypothesis implies that there is at least one false null hypothesis among those with p-values less than the specified tau value.Note: This method is equivalent to Fisher’s method when Tau=1.

Zaykin, D.V., Zhivotovsky, L.A., Westfall, P.H., and Weir, B.S. (2002). Truncated Product Method for Combining p-Values. Genetic Epidemiology 22: 170–185.

To Specify a P-Value Combination Method:For more information about these methods, see the Methods of Smoothing p-Values in the SAS/Genetics User's Guide.