Output Overview Descriptions | Clinical | Hy’s Law Screening

Hy’s Law Screening
Running this process with the Nicardipine sample setting generates the tabbed Results window shown below. Refer to the Hy’s Law Screening process description for more information. Output from the process is organized into tabs. Each tab contains one or more plots, data panels, data filters, or other elements that facilitate your analysis.
The Results window contains the following panes:
Tab Viewer
This pane provides you with a space to view individual tabs within the Results window. Use the tabs to access and view the output plots and associated data sets.
The following tabs are generated by this process:
Hy’s Law Screening: This tab displays an overall scatterplot of peak ALT, AST , BILI, and ALP measurements across the study, with color used to flag subjects meeting Hy's Law criteria.
Scatterplots: This tab displays scatterplots of peak ALT, AST, BILI, and ALP measurements across the study, with color used to flag subjects meeting Hy's Law criteria. Two contingency analyses show duration of Hy's Law and incidence of ALT or AST elevation by treatment.
3D Scatterplot (prior to JMP Clinical 4.1): This tab displays a 3-D scatterplot view of peak ALT, BILI, and AST lab measurements for each subject in a study.
Distributions (Hy’s Law Screening): This tab displays a set of histograms and summary statistics for the Hy's Law case counts, first day of Hy's Law events, AT test counts and first day of elevation along with demographics.
Tables: This tab contains tables corresponding to AT Test Elevation and Potential Hy’s Law Cases, as well as counts and percentages for elevation categories for each liver test.
Tests by Study Day: This tab contains a scatterplot matrix of four liver tests, plotting their peak values for each study day for each subject.
Missing Lab Test Summary: This tab contains a table showing counts of subjects for which the relevant Hy's Law lab tests were not measured.
Drill Down Buttons
Drill down buttons provide you with an easy way to drill down into your data.
The following drill down buttons are generated by this process:
Profile Subjects: Select subjects and click Profile Subjects to generate the patient profiles. See Profile Subjects for additional information.
Show Subjects: Select subjects and click Show Subjects to open the ADSL (or DM if ADSL is unavailable) of selected subjects.
Cluster Subjects: Select subjects and click Cluster Subjects to cluster them using data from available domains. See Cluster Subjects for additional information.
Create Subject Filter: Select subjects and click Create Subject Filter to create a data filter to be applied to subsequent processes to subset analyses.
Graph Time Profiles: Select subjects and click Graph Time Profiles to view a window of Hy’s Law Time Course Plots for each.
Graph Time Trends or Graph Trellis Plot (depending on version): Select subjects of interest from the results tabs (for example, subjects flagged as Hy's Law cases) and click Graph Time Trends or Graph Trellis Plot to display a trellis plot of lab time trends for ALT, AST, BILI, and ALP. A separate pane in the plot is generated for each subject, and the four lab tests are overlaid on the Y-axis with Study Day on the X-axis.
Launch Follow-Up Process
Follow up and extend the current analysis by launching and running a subsequent analysis.
Liver Lab Shift Plots: Click Liver Lab Shift Plots to launch and run liver labs (ALT, AST, ALP, BILI, or the LBTESTCD values that correspond to these tests) Shift Plots (and shift tables) via the Findings Shift Plots process on the data. This process (when accessed from a Launch Follow-Up Process button) currently runs using all subjects.
Click View Data to view the associated data table. Refer to View Data for more information.
Click Reopen Dialog to reopen the completed process dialog used to generate this output.
Click Create Report to generate a standardized pdf- or rtf-formatted report containing the plots and charts of selected tabs.
Click Add Notes to take notes, and store them in a central location. Refer to Add Notes for more information.
Click View Notes to read user-generated notes. Refer to View Notes for more information.
Click Close All to close all graphics windows and underlying data sets associated with the output.