JMP Clinical Basics | Data Sets | Sample Case Studies

Sample Case Studies
The following included data sets enable you to work through most of the reports. In addition to the data sets, each case study includes experimental design files and other needed files. These case studies are referred to throughout this manual.
These data came from a study of the effects of nicardipine on patients suffering from recent aneurismal subarachnoid hemorrhages (Clarke, et al. 1993a, 1993b). 906 patients were included in this randomized double-blind placebo-controlled study; 449 patients received nicardipine while 457 received the placebo. Patients in each group were balanced with regard to prognostic factors for overall outcome. Nicardipine and the placebo were delivered continuously at 0.15 mg/Kg/hr for up to 14 days and patients were followed for up to 120 days following administration of the drugs. Results are formatted according to the CDISC Study Tabulation Model (SDTM) and Analysis Data Model (ADaM).
Prostate Cancer Biomarkers
This data set was obtained by surface-enhanced laser desorption/ionization (SELDI). This method allows an investigator to detect and resolve multiple proteins bound to protein chip arrays (Merchant and Weinberger 2000). This approach was used by Qu et al. (2002) to discriminate prostate cancer from non-prostate cancer patients. The promise of this approach is that a panel of multiple biomarkers can be used to distinguish important phenotypes such as cancer status. However, great care must be taken to pre-process and analyze the data appropriately to ensure generalizability of results.
The example data set consists of serum samples collected from 165 men, 84 of whom had prostate cancer. The remaining 81 men are considered to be controls. The primary goal is to determine differences in protein expression between these groups.
Additional Data Sets
Some of the examples discussed in this manual use data sets, not included with JMP Clinical software, nor described here. Where applicable, these additional data sets are described in relevant chapters. We attempted to use publicly available data sets wherever possible, and have included instructions on where and how you can obtain these data as they are encountered in this manual.