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Publication date: 05/05/2023

Example of an Equivalence Test

Use the Oneway platform to investigate whether an alternative drug is not inferior to morphine for a procedure in dogs. We compare the difference in the first two time points.

1. Select Help > Sample Data Folder and open Dogs.jmp.

2. Select Analyze > Fit Y by X.

3. Select diff and click Y, Response.

4. Select drug and click X, Factor.

5. Click OK.

6. Click the Oneway Analysis red triangle menu and select Equivalence Tests > Means.

Figure 6.26 Equivalence or Noninferiority Tests Dialog 

Equivalence or Noninferiority Tests Dialog

7. Select Noninferiority (One-Sided).

8. Leave the variance assumption set to Pooled Variance.

9. Set the Difference to 1. This is the noninferiority margin.

10. Click OK.

Figure 6.27 Example of a Test for Noninferiority 

Example of a Test for Noninferiority

The observed difference in the response for the two drugs was -0.639 units. The lower bound on the confidence interval of -1.93 falls below the lower noninferiority limit of -1.0. We do not conclude that the alternative drug is not inferior to the standard drug.

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